Type 2 Diabetes – The Effect of Genetics on Diabetic Medications

Type 2 Diabetes – The Effect of Genetics on Diabetic Medications – Exciting research into genetics and how it will benefit diabetes continues. Coronary artery disease is a serious complication of diabetes and metformin, used for treating the condition, is also effective for preventing heart disease in some people. According to a report this year in the Russian medical journal Ter Arkh, in the future it could be possible to predict which patient will do well on metformin before it is actually prescribed…

24 men with coronary artery disease and the metabolic syndrome, and
28 men with coronary artery disease and Type 2 diabetes

were included in a study.
The men who had a gene called Pro benefited most when given metformin, showing a lowered waist measurement, body mass index, and blood levels of molecules associated with diabetes and heart disease.
It was therefore concluded, anyone who received Pro from both parents and who had either Type 2 diabetes or the metabolic syndrome, received the most benefit from being prescribed the anti-diabetic medication metformin. It was also suggested the effect be studied further.
Some day Type 2 diabetics and pre-diabetics could be routinely screened for the Pro gene and given metformin for lowering their risk of coronary artery disease if necessary. Those with other genes could be given some future medication tailor-made for their particular genetic makeup.
Another genetic study, reported on in October 2012 in the International Journal of Obesity, looked at which genes known to be associated with obesity could also contribute to insulin resistance and diabetes Type 2. Investigators at the Pasteur Institute and Nord de France University in Lille, France, first detected 24 genes known to be associated with obesity in:

2077 people diagnosed with Type 2 diabetes, and
3085 non-diabetics.

Then they measured insulin resistance, pancreatic beta cell function, insulin sensitivity, and blood insulin levels in all the study participants. Insulin resistance and a high risk of Type 2 diabetes were associated with several of the obesity genes.
One day it might be possible to take your child to a pediatrician for his or her regular checkups and have genetic screening done as part of the workup. If genes for insulin resistance, the hallmark of Type 2 diabetes, were found, you would be forewarned about the possible danger of developing the condition. You and your child’s doctor could plan with a blueprint for diet and physical activity to prevent your child from developing Type 2 diabetes.
Before genetic testing becomes routine in clinical settings, we can all benefit from a vegan diet with lots of variety and regular physical activity. Metformin is the standard medication prescribed for newly diagnosed cases of Type 2 diabetes.